بیوگرافی بینگ لیو | بینگ لیو: بیوگرافی بینگ لیو، بینگ لیو یکی از محققان چینی در دانشکده پزشکی دانشگاه پیتسبورگ آمریکا بود. بینگ لیو لیسانس و دکترای علوم کامپیوتر را با نظارت پروفسور P.S. تیاگاراجان و دیوید هسو از دانشگاه ملی سنگاپور گذراند. پیش از این، بینگ لیو با پروفسور کلارک جایزه تورینگ را در سال 2007 میلادی کسب نمود. در حال حاضر، بینگ لیو استادیار تحقیقاتی در گروه زیست شناسی محاسباتی سیستمهادر دانشکده پزشکی دانشگاه پیتسبورگ است. البته ایشان در روز 5 می 2020 به طرز مشکوکی کشته شد.
مدارک تحصیلی بینگ لیو
- 2002-2006: لیسانس علوم کامپیوتر، دانشگاه ملی سنگاپور
- 2006-2011: دکترای بیولوژی سیستمهای محاسباتی، دانشگاه ملی سنگاپور
بینگ لیو
بینگ لیو در مرکز تحقیقات در زمینه زیست شناسی سیستم های محاسباتی مستقر بود. لیو روشهای مدلسازی، شبیه سازی و تجزیه و تحلیل محاسباتی را برای مطالعه پویایی سیستمهای بیولوژیکی توسعه می دهد. بینگ لیو به عنوان بخش اساسی در تحقیقات من با تعدادی از زیست شناسان و پزشکان برای مطالعه انواع فرآیندهای مهم زیست شناختی مرتبط با ایمنی انسان و سرطان همکاری می کند. بینگ لیو همچنین از اهرم محاسباتی با کارایی بالا ، تأیید رسمی و تکنیک های یادگیری ماشین بهره می برد تا بتواند تجزیه و تحلیل سیستم های چند مقیاس را امکان پذیر کند. علاوه بر این ، بینگ لیو با استفاده از تکنیک هایی که من در حال توسعه برای تجزیه و تحلیل سیستم های فیزیکی سایبر که در برنامه های کاربردی دارای اهمیت حیاتی ایمنی هستند ، کاربرد دارد.
مقالات منتشر شده بینگ لیو
- W Sun, V Tyurin, G Mao, I Shrivastava, B Liu, Y Zhai, S Korolev, A Abramov, P Angelova, I Miller, O Beharier, H Dar, O Kapralov, T Hastings, J Greenamyre, C Chu, I Bahar, Y Sadovsky, H Bayır, Y Tyurina, R He, V Kagan iPLA2G6 Protects Cells against Ferroptosis by Hydrolyzing the Lipid Signal of Death, 15-HpETE-PE: Relevance to Parkinson Disease Pathogenesis, Nature Neuroscience, under review (2020).
PDF - B Liu. A Model Checking-based Analysis Framework for Systems Biology Models, The 57th ACM/IEEE Design Automation Conference (DAC), San Francisco, US (2020). IEEE, pp.1-6
PDF - Q Shi, F Pei, G Silverman, S Pak, D Perlmutter, B Liu, I Bahar. Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis, International Journal of Molecular Sciences, 21(8). 2855 (2020). doi: 10.3390/ijms21082855
PDF - S Thermozier, W Hou, X Zhang, D Shields, R Fisher, H Bayir, V Kagam, J Yu, B Liu, I Bahar, M W Epperly, P Wipf, H Wang, and J S Greenberger. Anti-Ferroptosis Drug Enhances Total Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis, Radiation Research, [Epub ahead of print] (2020). doi: 10.1667/RR15486.1
PDF - O Kapralov, Q Yang, H Dar, Y Tyurina, T Anthonymuthu, R Kim, C St. Croix, K Mikulska-Ruminska, B Liu, I Shrivastava, V Tyurin, H-C Ting, Y Wu, Y Gao, R Domingues, D Stoyanovsky, R Mallampalli, I Bahar, D Gabrilovich, H Bayir, and V Kagan Redox Lipid Reprogramming Commands Susceptibility of Macrophages and Microglia to Ferroptotic Death, Nature Chemical Biology, 16:2780-290 (2020). doi: 10.1038/s41589-019-0462-8
PDF - S Thermozier, X Zhang, W Hou, R Fisher, M W Epperly, B Liu, I Bahar, S Markovina, C Luke, G Silverman, and J S Greenberger. Radioresistance of Serpinb3a-/- Mice and Derived Hematopoietic and Marrow Stromal Cell Lines, Radiation Research, 192(3):267-281 (2019). doi: 10.1667/RR15379.1.
PDF - F Pei, H Li, B Liu, I Bahar. Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1, Frontiers in Pharmacology, 10:191 (2019). doi: 10.3389/fphar.2019.00191
PDF - B Liu, B Gyori, P S Thiagarajan. Statistical Model Checking based Analysis of Biological Networks Automated Reasoning for Systems Biology and Medicine, 63-92 (2019). doi: 10.1007/978-3-030-17297-8_3
PDF - J Steinman, M Epperly, Wen Hou, J Willis, H Wang, R Fisher, B Liu, I Bahar, T McCaw, V Kagan, H Bayir, J Yu, P Wipf, S Li, M S Huq, J S Greenberger. Improved Total Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways, Radiation Research, 189(1):68-83 (2018). doi: 10.1667/RR14787.1
PDF - J S Greenberger, B Liu, I Bahar, H Bayir, and V Kagan. Radiation Disease: Cytokines and the Stages of Apoptosis, Necroptosis, Ferroptosis, Parthanatos, Lysosomal Necrosis, Pyroptosis, and Overlapping Networks, Radiation Biology Methods, Chapter XII (2018).
PDF - J S Greenberger, B Liu, V Kagan, H Bayir, and I Bahar.Radiation Biologic Pathways Intersection and Integration with Other Pathways, Radiation Biology Methods, Chapter XIII (2018).
PDF - B Liu, Z Oltvai, H Bayir, G Silverman, S Pak, D Perlmutter, I Bahar. Quantitative Assessment of Cell Fate Decision between Autophagy and Apoptosis, Nature Scientific Reports, 7:17605 (2017).
PDF - V E Kagan, G Mao, F Qu, J P F Angeli, S Doll, C S Croix, H Dar, B Liu, V A Tyurin, V B Ritov, O A Kapralov, A A Amoscato, J Jiang, T Anthonymuthu, D Mohammadyani, Q Yang, J Klein-Seetharaman, S Watkins, I Bahar, J Greenberger, R Mallampalli, B R Stockwell, Y Y Tyurina, M Conrad, H Bayir. Oxidized Arachidonic and Adrenic PEs Navigate Cells to Ferroptosis, Nature Chemical Biology, 13:81-90 (2017). doi:10.1038/nchembio.2238.
PDF - B Liu, J R Faeder. Parameter Estimation of Rule-based Models Using Statistical Model Checking, IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Shenzhen, China (2016). IEEE, pp. 1458-1464.
PDF - Q Wang, N Miskov-Zivanov, B Liu, J R Faeder, M Lotze, E M Clarke. Formal Modeling and Analysis of Pancreatic Cancer Microenvironment, Computational Methods in Systems Biology (CMSB), Cambridge, UK (2016). Springer, LNCS:9859, pp. 289-305.
PDF - B Liu, Q Liu, S Palaniappan, L Yang, I Bahar, P S Thiagarajan, J L Ding. Innate Immune Memory and Homeostasis May Be Conferred Through crosstalk between TLR3 and TLR7 Pathways, Science Signaling, 9(436) ra70 (2016).
PDF - B Gyori, B Liu, S Paul, R Ramanathan, and P S Thiagarajan. Approximate Probabilistic Verification of Hybrid Systems. Hybrid Systems Biology (HSB), Madrid, Spain (2015). Springer, LNCS:9271, pp. 96-116.
PDF - C Kaya, B Liu, J R Faeder, I Bahar. Unified Model of Synaptic Transmission. Biophysical Journal, 108(2) 155a (2015).
PDF - G F Cooper, I Bahar, M J Becich, P V Benos, J Berg, J U Espino, C Glymour, R C Jacobson, M Kienholz, A V Lee, X Lu, R Scheines, Center for Causal Discovery team. The center for causal discovery of biomedical knowledge from big data Journal of the American Medical Informatics Association, 22(6):1132-1136 (2015).
PDF - B Liu, S Kong, S Gao, P Zuliani and E M Clarke. Towards Personalized Cancer Therapy Using Delta-Reachability Analysis. Hybrid Systems: Computation and Control (HSCC), Seattle, USA (2015). ACM, pp. 227-232.
PDF - B Liu, D Bhatt, Z N Oltvai, J S Greenberger, I Bahar. Significance of p53 Dynamics in Regulating Apoptosis in Response to Ionizing Radiation, and Polypharmacological Strategies. Nature Scientific Reports, 4:6245 (2014).
PDF - B Liu, S Kong, S Gao, P Zuliani and E M Clarke. Parameter Synthesis for Cardiac Cell Hybrid Models Using Delta-Decisions. Computational Methods in Systems Biology (CMSB), Manchester, UK (2014). Springer, LNCS:8859, pp. 99-113.
PDF - H Zhou, S Gao, N N Nguyen, M Fan, J Jin, B Liu, L Zhao, G Xiong, M Tan, S Li, L Wong. Stringent Homology-based Prediction of H. sapiens-M. tuberculosis H37Rv Protein-Protein Interactions. Biology Direct, 9(5):1-52 (2014).
PDF - A Hagiescu, B Liu, R. Ramanathan, S K Palaniappan, Z Cui, B Chattopadhyay, W F Wong, P S Thiagarajan. GPU Code Generation for ODE-Based Applications with Phased Shared-data Access Patterns. ACM Transactions on Architecture and Code Optimization, 10(4):551-5519 (2013).
PDF - S Palaniappan, B Gyori, B Liu, D Hsu, P S Thiagarajan and E M Clarke. Statistical Model Checking Based Calibration and Analysis of Bio-pathway Models. Computational Methods in Systems Biology (CMSB), Klosterneuburg, Austria (2013). Springer, LNCS:8130, pp 120-134.
PDF - B Liu, S Kong, S Gao, and E M Clarke. Parameter Identification Using Delta-Decisions for Biological Hybrid Systems. CMU SCS Technical Report, CMU-CS-13-136 (2013).
PDF - B Liu, A Hagiescu, S K Palaniappan, B Chattopadhyay, Z Cui, W F Wong, P S Thiagarajan. Approximate Probabilistic Analysis of Biopathway Dynamics. Bioinformatics, 28(11):1508-1516 (2012).
PDF - S K Palaniappan, S Akshay, B Liu, B Genest, P S Thiagarajan. A Hybrid Factored Frontier Algorithm for Dynamic Bayesian Networks with a Biopathways Application. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9(5):1352-1365 (2012).
PDF - B Liu, P S Thiagarajan. Modeling and Analysis of Biopathways Dynamics. Journal of Bioinformatics and Computational Biology, 10(4):1231001 (2012).
PDF - B Liu, J Zhang, P Y Tan, D Hsu, A M Blom, B Leong, S Sethi, B Ho, J L Ding, P S Thiagarajan. A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System. PLoS Computational Biology, 7(1):e1001059 (2011).
PDF News@NGS Website - B Liu, D Hsu, P S Thiagarajan. Probabilistic Approximations of ODEs based Bio-Pathway Dynamics. Theoretical Computer Science, 412(21):2188-2206 (2011).
PDF - B Liu, P S Thiagarajan, D Hsu. Probabilistic Approximations of Signaling Pathway Dynamics. Computational Methods in Systems Biology (CMSB) , Bologna, Italy (2009). Springer, LNCS:5688, pp. 251-265.
PDF - B Liu. Statistical analysis of partially calibrated bio-pathway models. HPC E-newsletter Issue No. 24. (HPC Challenge 2009 Winning Project) (2009).
PDF - T Zhu, P Korshunov, B Liu, W T Ooi. Plasma: A Scripting Language for Processing Media Streams. ACM/SPIE Multimedia Computing and Networking (MMCN), San Jose, US (2007). Proceedings of SPIE:6504, pp. 65040Q.
PDF - B Liu, W T Ooi. SLIME: A Tool for Composing Live and Stored Media. In Proc. of the 11th NUROP Congress, Singapore (2006).
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